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5-Amino-1MQ

5-Amino-1MQ

$58.00
$58.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

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5-Amino-1MQ

5-Amino-1MQ

$58.00
$58.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that regulates cellular energy metabolism. By blocking NNMT activity, it has been shown in preclinical studies to enhance NAD⁺ availability, increase metabolic rate, and reduce adiposity.

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  • DESCRIPTION
  • STORAGE
  • REFERENCES

Overview

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small, membrane-permeable analogue of methylquinolinium recognized for its ability to inhibit nicotinamide N-methyltransferase (NNMT). NNMT plays a crucial role in metabolic regulation and has been implicated in obesity, insulin resistance, and type 2 diabetes. By suppressing NNMT activity, 5-Amino-1MQ has been shown in preclinical research to reduce fat mass, decrease adipocyte size, lower plasma cholesterol and glucose, and stimulate stem cell activation—enhancing regenerative potential in skeletal muscle.

Structure

  • Molecular Formula: C₁₂H₁₃N₅
  • Molecular Weight: 159.21 g/mol
  • CAS Number: 42446-96-0
  • PubChem CID: 950107
  • Synonyms: 5-amino-1-methylquinolinium

Research

Obesity & Metabolism

NNMT is highly expressed in liver and adipose tissue. Elevated levels of this enzyme are associated with decreased activity of the glucose transporter GLUT4, which is essential for glucose uptake in muscle and fat cells. Reduced GLUT4 function promotes insulin resistance and diabetes. In animal models, 5-Amino-1MQ restored GLUT4 activity, improved glucose clearance, enhanced energy metabolism, and significantly reduced fat accumulation.

Key outcomes include:

  • ~7% reduction in body mass within 10 days
  • 30% decrease in fat mass
  • Lower plasma cholesterol
  • Improved insulin sensitivity

    These effects occurred without altering food intake, indicating the mechanism is metabolic rather than appetite-driven.

Muscle Function

NNMT inhibition also influences skeletal muscle. By stimulating muscle stem cells and enhancing GLUT4 activity, 5-Amino-1MQ supports muscle regeneration and metabolic efficiency. In studies with aged mice, NNMT blockade doubled myofiber cross-sectional size and improved contractile strength by ~70%. These findings suggest possible therapeutic value for age-related muscle loss and degenerative conditions such as muscular dystrophy.

Cognition

NAD⁺ depletion is linked to impaired synaptic signaling, neuromuscular function, and overall energy homeostasis in the brain. Since 5-Amino-1MQ raises NAD⁺ levels through NNMT inhibition, researchers suggest it may protect against age-related cognitive decline and support neuronal communication, though direct human studies are limited.

Cancer Research

Overexpression of NNMT has been observed in cancers such as gastric, pancreatic, renal, and bladder tumors. Animal studies indicate that NNMT deficiency reduces tumor progression, suggesting that NNMT inhibition could help limit cancer aggressiveness. Although clinical translation is still under investigation, these findings position 5-Amino-1MQ as a compound of interest in oncology research.

Summary

5-Amino-1MQ is a potent NNMT inhibitor that influences metabolism, regeneration, and cellular energy regulation. Research highlights include:

  • Reduction in body weight and fat mass
  • Improved glucose handling and insulin sensitivity
  • Lower cholesterol levels
  • Enhanced muscle repair and strength
  • Potential protective roles in cognition and cancer models

Its link to NAD⁺ metabolism and sirtuin pathways underscores its broad relevance in research on aging, metabolic disorders, and regenerative biology.

This product is provided as a lyophilized powder. For best results, store vials in a cool, dry environment at 2 °C to 8 °C (refrigerated), protected from light and moisture. Once reconstituted, solutions should be kept sterile and used promptly to ensure stability. For long-term preservation, unopened vials may be stored at −20 °C, with repeated freeze–thaw cycles avoided to maintain compound integrity. Always handle according to standard laboratory safety protocols for research-use-only materials.

1. Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508(7495):258–262. doi:10.1038/nature13198

2. Carvalho E, Kotani K, Peroni OD, Kahn BB. Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle. Am J Physiol Endocrinol Metab. 2005;289(4):E551–E561. doi:10.1152/ajpendo.00116.2005

3. Neelakantan H, Brightwell CR, Graber TG, Maroto R, Zhu J, Morrell CN, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet–induced obesity in mice. Biochem Pharmacol. 2017;147:141–152. doi:10.1016/j.bcp.2017.11.007

4. Moraes-Vieira PM, Saghatelian A, Kahn BB. GLUT4 expression in adipocytes regulates de novo lipogenesis and levels of a novel class of lipids with antidiabetic and anti-inflammatory effects. Diabetes. 2016;65(7):1808–1815. doi:10.2337/db16-0221

5. Neelakantan H, Vance JA, Wagner GR, Ghosh AK. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019;163:140–148. doi:10.1016/j.bcp.2019.02.008

6. Pissios P. Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme. Trends Endocrinol Metab. 2017;28(5):340–353. doi:10.1016/j.tem.2017.02.004

7. Ryu D, Zhang H, Ropelle ER, Sorrentino V, Mázala DA, Mouchiroud L, et al. NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med. 2016;8(361):361ra139. doi:10.1126/scitranslmed.aaf5504

8. Lundt S, Zhang N, Wang X, Polo-Parada L, Ding S. The effect of NAMPT deletion in projection neurons on the function and survival of neuromuscular junctions. Sci Rep. 2016;6:24234. doi:10.1038/srep24234

9. Ninos J, Carmona-Gutierrez D, Madeo F. Polyamines in aging and disease. Aging. 2011;3(8):716–732. doi:10.18632/aging.100361

10. Recherche Animale. Weight loss without effort: NNMT inhibitors. 2020. Available at: https://www.recherche-animale.org/en/weight-loss-without-effort-nnmt-inhibitors