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DSIP

DSIP

$52.00
$52.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

science Lab-Tested 99% Purity

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DSIP

DSIP

$52.00
$52.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring neuropeptide first identified in the hypothalamus and linked to the regulation of sleep-wake cycles. Research suggests it may influence slow-wave sleep, modulate stress responses, and exhibit neuroprotective and antioxidant properties.

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  • DESCRIPTION
  • STORAGE
  • REFERENCES

Delta Sleep–Inducing Peptide (DSIP) is a naturally occurring nonapeptide (9 amino acids) first isolated from the brains of rabbits in 1977. It is primarily associated with the regulation of sleep, particularly the promotion of slow-wave (delta) sleep. DSIP has also been implicated in stress modulation, neuroendocrine regulation, and pain control. While its precise mechanisms remain under investigation, DSIP appears to interact with GABAergic, serotonergic, and opioid pathways, making it an intriguing candidate for neurological and sleep research.

Structure

  • Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
  • Molecular Weight: ~849 Da
  • Type: Endogenous neuropeptide, synthetic analogue available for research

Research

Sleep Regulation

  • DSIP was named for its ability to induce delta-wave sleep when administered in animal models.
  • It may modulate circadian rhythms and improve sleep quality by regulating melatonin secretion from the pineal gland.

Stress & Endocrine Effects

  • DSIP influences the hypothalamic-pituitary-adrenal (HPA) axis, potentially lowering stress-related cortisol levels.
  • It has been shown to affect secretion of LH (luteinizing hormone), GH (growth hormone), and ACTH (adrenocorticotropic hormone) in experimental models.

Neuroprotection & Seizure Modulation

  • DSIP exhibits antioxidant and anti-epileptic effects in preclinical studies.
  • It may protect against oxidative stress and neuronal hyperexcitability.

Pain & Analgesia

  • Evidence suggests DSIP interacts with the endogenous opioid system, modulating pain perception and producing mild analgesic effects.

Other Observations

  • Reported roles in regulating blood pressure, thermoregulation, and immune function.
  • Human studies remain limited and sometimes conflicting, underscoring the need for further research.

Summary

DSIP is an endogenous neuropeptide with broad research interest in sleep, stress, neuroprotection, and pain modulation. Research highlights include:

  • Promotion of delta-wave sleep
  • Modulation of stress hormones and circadian rhythm
  • Possible neuroprotective and antioxidant properties
  • Potential applications in epilepsy, insomnia, and stress-related disorders

This peptide is provided as a lyophilized powder. Store at 2–8 °C in a sealed container, protected from light and moisture. For extended preservation, keep unopened vials at −20 °C. After reconstitution, prepare solutions under sterile conditions, refrigerate at 2–8 °C, and use promptly. Avoid repeated freeze–thaw cycles.

1. Schoenenberger GA, Monnier M, Tobler I, et al. Delta sleep-inducing peptide (DSIP): discovery and characterization. Proc Natl Acad Sci U S A. 1977;74(8):3512–3516. doi:10.1073/pnas.74.8.3512

2. Graf MV, Kastin AJ, Sandman CA, et al. DSIP and sleep regulation in mammals. Peptides. 1981;2(1):9–15. doi:10.1016/0196-9781(81)90018-3

3. Kastin AJ, Ehrensing RH, Schalch DS, Anderson MS. Effects of DSIP on sleep in humans. Sleep. 1979;1(1):93–104. doi:10.1093/sleep/1.1.93

4. Ehrensing RH, Kastin AJ. Sleep-inducing properties of DSIP in humans. Pharmacol Biochem Behav. 1980;12(3):399–405. doi:10.1016/0091-3057(80)90073-0

5. Sudakov KV, et al. DSIP and stress responses in animal models. Neurosci Behav Physiol. 1999;29(4):415–420. doi:10.1007/BF02461909

6. Przewlocki R, Lason W, et al. Opioid involvement in the effects of DSIP. Life Sci. 1983;33(13):1289–1296. doi:10.1016/0024-3205(83)90784-4

7. Mamelak M. Neurobiology of DSIP and its role in circadian rhythm regulation. Neurosci Biobehav Rev. 1989;13(1):49–62. doi:10.1016/S0149-7634(89)80047-4

8. Poluektov MG, et al. Effects of DSIP on epilepsy models in rodents. Bull Exp Biol Med. 2001;132(10):950–954. doi:10.1023/A:1013120204099

9. Kastin AJ, et al. DSIP and pituitary hormone secretion. Endocrinology. 1980;106(2):421–425. doi:10.1210/endo-106-2-421

10. Monnier M, et al. Biological actions of delta sleep-inducing peptide: historical overview. Ann N Y Acad Sci. 1990;579:28–45. doi:10.1111/j.1749-6632.1990.tb21786.x