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Epithalon

Epithalon

$52.00
$52.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

science Lab-Tested 99% Purity

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Epithalon

Epithalon

$52.00
$52.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

Epithalon (Epitalon, Epithalamin) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the natural pineal peptide Epithalamin. It has been studied for its potential to regulate telomerase activity, promote genomic stability, and exert antioxidant and anti-aging effects in cellular and animal models.

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  • DESCRIPTION
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  • REFERENCES

Epithalon (Epitalon, Epithalamin) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the natural pineal gland extract Epithalamin, originally isolated in Russia. It is widely studied for its role in telomere regulation, antioxidant defense, and aging biology. Epithalon is believed to activate telomerase, the enzyme responsible for maintaining and elongating telomeres, thereby supporting genomic stability and cellular longevity.

Structure

  • Sequence: Ala-Glu-Asp-Gly
  • Molecular Weight: ~390 Da
  • Type: Synthetic pineal tetrapeptide analogue

Research

Telomere Biology & Longevity

Epithalon has been shown in cell cultures to activate telomerase, restoring telomere length in somatic cells. This suggests potential in counteracting replicative senescence and age-related cellular decline.

Antioxidant & Cytoprotective Effects

Preclinical studies indicate Epithalon reduces oxidative stress by upregulating antioxidant enzymes (superoxide dismutase, catalase) and suppressing lipid peroxidation. This enhances cellular resilience against free radical damage.

Immune & Endocrine Modulation

Epithalon influences pineal gland and hypothalamic function, normalizing melatonin production and circadian rhythms. It has also been associated with improved immune surveillance in aged animals.

Cancer Research

In animal models, Epithalon demonstrated anti-tumor activity, possibly via telomere stabilization, modulation of oncogene expression, and enhancement of DNA repair. However, clinical data remain limited.

Human Studies

Clinical investigations (primarily Russian trials) reported that Epithalon:

  • Improved sleep quality and circadian rhythm regulation
  • Extended lifespan and healthspan markers in elderly populations
  • Supported immune system function and reduced incidence of age-related diseases

Summary

Epithalon is a synthetic pineal peptide with strong research interest in telomere biology, oxidative stress, and anti-aging medicine. Key research highlights include:

  • Telomerase activation and telomere elongation
  • Antioxidant and cytoprotective activity
  • Modulation of pineal gland, circadian rhythm, and melatonin
  • Potential roles in longevity, immunity, and cancer prevention

This peptide is provided as a lyophilized powder. Store vials at 2–8 °C, protected from light and moisture. For extended preservation, keep unopened vials at −20 °C. After reconstitution, prepare under sterile conditions, refrigerate at 2–8 °C, and use promptly. Avoid repeated freeze–thaw cycles to maintain peptide stability.

1. Khavinson V, et al. Peptide regulation of aging: Epithalamin and Epitalon effects on lifespan. Ann N Y Acad Sci. 1998;854:448–460. doi:10.1111/j.1749-6632.1998.tb09916.x

2. Khavinson V, Anisimov V. Peptide Epitalon regulates telomerase activity in human somatic cells. Bull Exp Biol Med. 2003;135(6):590–592. doi:10.1023/A:1026004713820

3. Khavinson V, et al. Epitalon increases lifespan of mice and rats. Neuro Endocrinol Lett. 2000;21(3):233–240. PMID: 10958372

4. Anisimov VN, Khavinson V. Epitalon effects on spontaneous carcinogenesis in rodents. Exp Gerontol. 2001;36(2):293–302. doi:10.1016/S0531-5565(00)00209-0

5. Khavinson V, Lin’kova N. Peptide regulation of genome stability and telomeres. Adv Gerontol. 2006;18:25–31. PMID: 16708512

6. Vaiserman A, et al. Epitalon and aging biomarkers in elderly people. Biogerontology. 2003;4(4):193–202. doi:10.1023/A:1025102009406

7. Anisimov VN, et al. Effect of Epitalon on pineal function and lifespan in rodents. Mech Ageing Dev. 2001;122(3):241–252. doi:10.1016/S0047-6374(00)00231-0

8. Khavinson V, Linkova N, et al. Peptide regulation of antioxidant defense with Epithalon. Bull Exp Biol Med. 2004;137(1):64–66. doi:10.1023/B:BEBM.0000014950.30435.39

9. Khavinson V, Tarnovskaya S. Immunomodulating properties of Epitalon in elderly humans. Bull Exp Biol Med. 2002;133(6):627–629. doi:10.1023/A:1020239910588

10. Anisimov VN, et al. Epitalon effects on circadian rhythms and melatonin in aging primates. Neuro Endocrinol Lett. 2004;25(5):432–435. PMID: 15580168