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Follistatin

Follistatin

$112.00
$112.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

science Lab-Tested 99% Purity

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Follistatin

Follistatin

$112.00
$112.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

Follistatin is a glycoprotein that binds and neutralizes members of the TGF-β superfamily, particularly myostatin and activin. By inhibiting these signaling pathways, it has been investigated for its ability to promote muscle growth, enhance regeneration, and modulate reproductive and metabolic processes.

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  • DESCRIPTION
  • STORAGE
  • REFERENCES

Follistatin is a glycoprotein and autocrine regulatory protein best known for its ability to bind and neutralize activins (members of the TGF-β superfamily). It is also a potent myostatin inhibitor, giving it broad interest in muscle growth, regeneration, and metabolic research. By blocking myostatin and other activins, Follistatin shifts cellular signaling toward muscle hypertrophy, tissue repair, and anabolic processes. Synthetic and recombinant forms of Follistatin (such as FST344 and FST315) are studied for their therapeutic potential.

Structure

  • Type: Glycoprotein, ~35–40 kDa
  • Isoforms: FST344 (circulating), FST315 (shorter form)
  • Mechanism: Binds and neutralizes activins, myostatin, and other TGF-β ligands

Research

Muscle Growth & Regeneration

  • Follistatin’s inhibition of myostatin (GDF-8) promotes skeletal muscle hypertrophy.
  • In animal models, follistatin overexpression or administration produces dramatic muscle mass increases and improved strength.
  • Interest exists in its potential application for muscular dystrophies and sarcopenia.

Metabolic Effects

  • Inhibition of activin/myostatin pathways has been linked to improved insulin sensitivity and lipid metabolism in animal studies.
  • May play a role in combating obesity and type 2 diabetes by enhancing lean mass and reducing fat mass.

Fertility & Reproduction

  • Follistatin regulates pituitary FSH secretion by binding activins.
  • Its role in ovarian and testicular physiology is under investigation for fertility research.

Anti-Fibrotic & Regenerative Medicine

  • Follistatin has demonstrated anti-fibrotic properties in liver, kidney, and cardiac tissues by modulating TGF-β signaling.
  • It promotes wound healing and tissue repair, making it of interest in regenerative medicine.

Safety Profile

  • Preclinical studies indicate strong anabolic effects with minimal adverse outcomes.
  • Long-term safety in humans remains under investigation.

Summary

Follistatin is a potent binding protein for activins and myostatin, making it a powerful modulator of muscle growth and tissue regeneration. Research highlights include:

  • Myostatin inhibition and skeletal muscle hypertrophy
  • Metabolic improvements in obesity and diabetes models
  • Anti-fibrotic effects in liver, kidney, and heart
  • Regulatory role in fertility and reproduction

Its multifunctional actions place Follistatin at the crossroads of muscle biology, regenerative medicine, and metabolic health research.

This product is supplied as a lyophilized peptide/protein. Store at 2–8 °C, protected from light and moisture. For extended preservation, store unopened vials at −20 °C. After reconstitution, solutions should be prepared under sterile conditions, stored refrigerated (2–8 °C), and used promptly. Avoid repeated freeze–thaw cycles to maintain protein stability.

1. Lee SJ, McPherron AC. Regulation of myostatin activity and muscle growth by Follistatin. Proc Natl Acad Sci U S A. 2001;98(16):9306–9311. doi:10.1073/pnas.151270098

2. Haidet AM, et al. Long-term enhancement of skeletal muscle mass and strength by Follistatin gene delivery. Nat Med. 2008;14(4):442–446. doi:10.1038/nm1739

3. Amthor H, et al. Muscle hypertrophy driven by Follistatin antagonism of myostatin. EMBO J. 2004;23(3):479–489. doi:10.1038/sj.emboj.7600291

4. Zhu J, et al. Recombinant Follistatin enhances muscle regeneration and strength after injury. Mol Ther. 2011;19(1):103–111. doi:10.1038/mt.2010.221

5. Nakatani M, et al. Transgenic expression of a Follistatin-derived peptide increases muscle mass. Nat Biotechnol. 2008;26(3):313–319. doi:10.1038/nbt1384

6. Braga M, et al. Follistatin promotes brown adipose tissue function and metabolic health. Nat Commun. 2014;5:4676. doi:10.1038/ncomms5676

7. Yaden BC, et al. Follistatin administration improves glucose homeostasis in mice. Endocrinology. 2014;155(6):2109–2121. doi:10.1210/en.2013-2046

8. Schneyer AL, et al. Follistatin antagonism of activin regulates reproductive physiology. Endocr Rev. 2004;25(5):856–874. doi:10.1210/er.2003-0035

9. Patel K, Amthor H. The function of myostatin and Follistatin in muscle development. Novartis Found Symp. 2000;225:109–116. doi:10.1002/0470846534.ch8

10. Elashry MI, et al. Anti-fibrotic effects of Follistatin in liver and kidney injury models. Front Pharmacol. 2022;13:846139. doi:10.3389/fphar.2022.846139