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Glutathione

Glutathione

$72.00
$72.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

science Lab-Tested 99% Purity

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Glutathione

Glutathione

$72.00
$72.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

Glutathione is a tripeptide (γ-L-glutamyl-L-cysteinyl-glycine) that functions as a major intracellular antioxidant. It plays a central role in redox balance, detoxification, and cellular defense against oxidative stress, and has been studied for its potential in supporting immune function, liver health, and skin brightening.

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  • DESCRIPTION
  • STORAGE
  • REFERENCES

Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycine, and is the most abundant endogenous antioxidant in mammalian cells. It plays a central role in redox balance, detoxification, immune function, and cellular defense against oxidative stress. GSH exists in reduced (GSH) and oxidized (GSSG) forms, with the GSH/GSSG ratio serving as a critical marker of cellular oxidative status.

Structure

  • Sequence: γ-L-Glutamyl-L-cysteinyl-glycine
  • Molecular Weight: ~307 Da
  • Form: Tripeptide, typically studied in reduced form (GSH)
  • Mechanism: Directly scavenges free radicals, serves as a cofactor for antioxidant enzymes, and regulates detoxification pathways

Research

Antioxidant & Redox Regulation

  • Neutralizes reactive oxygen species (ROS) and reactive nitrogen species (RNS).
  • Supports the activity of glutathione peroxidase, glutathione reductase, and glutathione S-transferases.
  • Maintains cellular thiol status and prevents oxidative damage to DNA, proteins, and lipids.

Detoxification

  • Conjugates with toxins, heavy metals, and xenobiotics to facilitate excretion via the mercapturic acid pathway.
  • Plays a major role in liver detoxification and protection against drug- or alcohol-induced hepatotoxicity.

Immune Function

  • Essential for lymphocyte proliferation, cytokine regulation, and NK cell activity.
  • Enhances immune resilience by supporting redox-sensitive signaling pathways.

Skin & Aesthetic Research

  • Studied for skin-lightening effects by inhibiting tyrosinase activity and altering melanin synthesis.
  • Used in cosmetic formulations and IV research protocols for aesthetic applications.

Neurological & Aging Research

  • Supports mitochondrial function and protects neurons against oxidative stress, relevant in Parkinson’s, Alzheimer’s, and neurodegenerative diseases.
  • GSH decline is strongly associated with aging, chronic disease, and cellular senescence.

Summary

Glutathione (GSH) is the body’s master antioxidant and detoxifier, crucial for maintaining cellular redox homeostasis. Research highlights include:

  • Direct scavenging of ROS and RNS
  • Central role in detoxification and liver protection
  • Immune-enhancing and anti-inflammatory properties
  • Applications in skin lightening, anti-aging, and neuroprotection

Its multifunctional role in antioxidant defense makes it one of the most important molecules in cellular health research.

This product is supplied as a lyophilized powder. Store vials at 2–8 °C, protected from light and moisture. For long-term storage, keep unopened vials at −20 °C. After reconstitution, prepare under sterile conditions, refrigerate at 2–8 °C, and use promptly. Avoid repeated freeze–thaw cycles.

1. Pompella A, et al. The changing faces of glutathione, a cellular protagonist. Biochem Pharmacol. 2003;66(8):1499–1503. doi:10.1016/S0006-2952(03)00504-5

2. Wu G, Fang YZ, Yang S, et al. Glutathione metabolism and its implications for health. J Nutr. 2004;134(3):489–492. doi:10.1093/jn/134.3.489

3. Dröge W. The role of cysteine and glutathione in oxidative stress and aging. Biol Chem. 2002;383(3-4): 521–536. doi:10.1515/BC.2002.054

4. Townsend DM, Tew KD, Tapiero H. The importance of glutathione in human disease. Biomed Pharmacother. 2003;57(3-4):145–155. doi:10.1016/S0753-3322(03)00043-X

5. Franco R, Schoneveld O, Pappa A, Panayiotidis MI. The central role of glutathione in redox homeostasis. Cell Mol Life Sci. 2007;64(19-20):2130–2148. doi:10.1007/s00018-007-7031-2

6. Ballatori N, et al. Glutathione metabolism and function in liver. Toxicol Appl Pharmacol. 2009;238(3):229–238. doi:10.1016/j.taap.2009.04.012

7. Witschi A, et al. The systemic availability of oral glutathione. Eur J Clin Pharmacol. 1992;43(6):667–669. doi:10.1007/BF02284971

8. Aoyama K, et al. Role of glutathione in neuroprotection and neurodegeneration. Neurochem Int. 2008;52(4-5):726–734. doi:10.1016/j.neuint.2007.06.007

9. Arjinpathana N, Asawanonda P. Glutathione as an oral whitening agent. J Dermatolog Treat. 2012;23(2):97–102. doi:10.3109/09546634.2010.536240

10. Richie JP, et al. Glutathione supplementation and its effects on oxidative stress biomarkers. Eur J Nutr. 2015;54(2):251–263. doi:10.1007/s00394-014-0706-z