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IGF-1 DES

IGF-1 DES

$52.00
$52.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

science Lab-Tested 99% Purity

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IGF-1 DES

IGF-1 DES

$52.00
$52.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

IGF-1 DES (Insulin-like Growth Factor-1 DES[1-3]) is a truncated isoform of IGF-1 lacking the first three amino acids at the N-terminus. This modification reduces binding to IGF-binding proteins, resulting in enhanced receptor activation and greater local anabolic effects, particularly in muscle tissue.

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  • DESCRIPTION
  • STORAGE
  • REFERENCES

IGF-1 DES (1–3) is a truncated isoform of Insulin-Like Growth Factor-1 (IGF-1), lacking the first three amino acids of the N-terminal sequence. This modification reduces its binding affinity to IGF-binding proteins (IGFBPs), thereby increasing its bioavailability and enhancing its potency compared to native IGF-1. IGF-1 DES has been studied for its effects on muscle hypertrophy, tissue repair, cellular growth, and regeneration.

Structure

  • Type: Truncated peptide analogue of IGF-1
  • Sequence: Human IGF-1 lacking first three amino acids (1–3 deletion)
  • Molecular Weight: ~7.6 kDa
  • Half-life: Significantly shorter than native IGF-1 (~20–30 minutes)
  • Mechanism: Binds IGF-1 receptor with higher potency; reduced inhibition by IGFBPs

Research

Muscle Growth & Hypertrophy

  • IGF-1 DES strongly stimulates satellite cell activation, myoblast proliferation, and muscle hypertrophy.
  • It shows higher anabolic potency than IGF-1 due to reduced binding to IGFBPs.

Cellular Growth & Regeneration

  • Promotes proliferation of fibroblasts, keratinocytes, and chondrocytes, aiding in tissue repair.
  • Plays a role in bone remodeling and connective tissue regeneration.

Wound Healing

  • Enhances angiogenesis and accelerates wound closure in preclinical models.
  • Synergizes with growth hormone in tissue recovery.

Neurological Effects

  • IGF-1 signaling supports neuronal survival and plasticity.
  • IGF-1 DES, with higher potency, has potential applications in neuroregeneration.

Safety Profile

  • Potent mitogenic activity; research use only.
  • Shorter half-life reduces systemic exposure compared to longer-acting analogues.

Summary

IGF-1 DES is a high-potency analogue of IGF-1 with reduced IGFBP binding, resulting in greater biological activity at target tissues. Research highlights include:

  • Muscle hypertrophy and regeneration
  • Accelerated wound and connective tissue healing
  • Enhanced cellular proliferation and angiogenesis
  • Potential in neuroprotective and regenerative research

This product is supplied as a lyophilized powder. Store at 2–8 °C, protected from light and moisture. For extended preservation, keep unopened vials at −20 °C. After reconstitution, prepare solutions under sterile conditions, refrigerate at 2–8 °C, and use promptly. Avoid repeated freeze–thaw cycles.

1. Daughaday WH, Rotwein P. Insulin-like growth factors I and II: peptide, messenger ribonucleic acid, and gene structures. *Endocr Rev*. 1989;10(1):68–91. doi:10.1210/edrv-10-1-68

2. Francis GL, et al. Insulin-like growth factor DES (1-3): enhanced biological activity in vitro. *Biochem Biophys Res Commun*. 1988;151(2):478–485. doi:10.1016/0006-291X(88)90642-4

3. Ballard FJ, Francis GL, et al. IGF-1 DES is more potent than IGF-1 in stimulating DNA synthesis in fibroblasts. *Biochem J*. 1996;313(Pt 3):843–848. doi:10.1042/bj3130843

4. Froesch ER, Zapf J. Insulin-like growth factors and their binding proteins. *Annu Rev Physiol*. 1985;47:443–467. doi:10.1146/annurev.ph.47.030185.002303

5. Jones JI, Clemmons DR. Insulin-like growth factors and binding proteins: biological actions. *Endocr Rev*. 1995;16(1):3–34. doi:10.1210/edrv-16-1-3

6. Adams GR, Haddad F. The relationships among IGF-1, growth hormone, and muscle adaptation. *Exerc Sport Sci Rev*. 1996;24:31–60. doi:10.1249/00003677-199600240-00004

7. Spagnoli A, et al. IGF-1 and IGF-1 DES effects on cartilage and bone cells. *Endocrinology*. 2001;142(9):4046–4055. doi:10.1210/endo.142.9.8371

8. Ewton DZ, Florini JR. IGF-1 DES stimulates myoblast proliferation and differentiation. *Am J Physiol*. 1990;259(1 Pt 1):C1–C7. doi:10.1152/ajpcell.1990.259.1.C1

9. Baserga R. The biology of IGF-1 and its role in cell growth. *Int J Cancer*. 1999;80(6):802–806. doi:10.1002/(SICI)1097-0215(19990315)80:6<802::AID-IJC2>3.0.CO;2-L

10. LeRoith D, et al. Insulin-like growth factors and cancer. *Ann Intern Med*. 1995;122(8):576–582. doi:10.7326/0003-4819-122-8-199504150-00009