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Kisspeptin-10

Kisspeptin-10

$52.00
$52.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

science Lab-Tested 99% Purity

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Kisspeptin-10

Kisspeptin-10

$52.00
$52.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

Kisspeptin-10 is a synthetic decapeptide fragment of the kisspeptin protein family that plays a critical role in regulating the hypothalamic-pituitary-gonadal (HPG) axis. It stimulates the release of gonadotropin-releasing hormone (GnRH), thereby influencing reproductive hormone secretion and fertility.

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  • DESCRIPTION
  • STORAGE
  • REFERENCES

Kisspeptin-10 (KP-10) is a synthetic decapeptide fragment of kisspeptin, a neuropeptide encoded by the KISS1 gene. Kisspeptins act as natural ligands for the G-protein coupled receptor GPR54 (KISS1R), which plays a pivotal role in reproductive endocrinology and puberty initiation. KP-10 is the most biologically active fragment of the kisspeptin family and is extensively studied for its role in GnRH secretion, fertility, cancer biology, and metabolism.

Structure

  • Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
  • Length: 10 amino acids (bioactive fragment of kisspeptin)
  • Molecular Weight: ~1300 Da
  • Mechanism: Activates KISS1R → stimulates hypothalamic GnRH release → induces LH and FSH secretion

Research

Reproductive Axis Regulation

  • KP-10 is a potent stimulator of GnRH neurons, leading to increased LH and FSH secretion.
  • Critical for puberty onset and maintenance of fertility.
  • Studied as a diagnostic tool for evaluating hypogonadotropic hypogonadism and delayed puberty.

Fertility & ART Research

  • In women, KP-10 induces LH surges, mimicking the natural ovulatory signal.
  • In men, KP-10 stimulates testosterone secretion via LH induction.
  • Investigated as an alternative to HCG or GnRH analogues in assisted reproductive technologies (ART).

Cancer Biology

  • KISS1 was first identified as a metastasis suppressor gene in melanoma and breast cancer.
  • KP-10 inhibits tumor invasion and metastasis in experimental cancer models.

Metabolism & Other Roles

  • Evidence suggests KP-10 may influence insulin secretion, appetite regulation, and vascular function.
  • Ongoing research explores its role in neuroendocrine and metabolic integration.

Safety Profile

  • Well tolerated in research settings.
  • Responses are acute and dose-dependent, with transient LH/FSH elevations.

Summary

Kisspeptin-10 is the most potent kisspeptin fragment, central to reproductive hormone regulation and fertility research. Key highlights include:

  • Stimulates GnRH, LH, and FSH release
  • Essential in puberty onset and fertility
  • Potential tool in diagnosis and treatment of hypogonadism
  • Investigated as a metastasis suppressor and regulator of cancer progression

This peptide is supplied as a lyophilized powder. Store at 2–8 °C, protected from light and moisture. For long-term preservation, keep unopened vials at −20 °C. After reconstitution, prepare under sterile conditions, refrigerate at 2–8 °C, and use promptly. Avoid repeated freeze–thaw cycles.

1. Kotani M, et al. The metastasis suppressor gene product KiSS-1 is a ligand of the orphan G-protein-coupled receptor GPR54. *J Biol Chem*. 2001;276(27):34631–34636. doi:10.1074/jbc.M104847200

2. Seminara SB, et al. The GPR54 gene as a regulator of puberty. *N Engl J Med*. 2003;349(17):1614–1627. doi:10.1056/NEJMoa035322

3. Navarro VM, et al. Direct action of kisspeptins on GnRH neurons. *Proc Natl Acad Sci U S A*. 2005;102(48):17601–17606. doi:10.1073/pnas.0507902102

4. Jayasena CN, et al. Kisspeptin-54 triggers gonadotropin release in men. *J Clin Endocrinol Metab*. 2009;94(12):5116–5125. doi:10.1210/jc.2009-1320

5. George JT, et al. Kisspeptin-10 stimulates GnRH release in women with hypothalamic amenorrhea. *J Clin Endocrinol Metab*. 2011;96(3):E536–E545. doi:10.1210/jc.2010-2690

6. Dhillo WS, et al. Kisspeptin as a novel therapeutic for reproductive health. *Trends Endocrinol Metab*. 2007;18(9):448–454. doi:10.1016/j.tem.2007.10.001

7. Mead EJ, Maguire JJ, Kuc RE, Davenport AP. Kisspeptins are novel vasoconstrictors in humans. *Br J Pharmacol*. 2007;151(5):707–717. doi:10.1038/sj.bjp.0707289

8. Stafford LJ, et al. The metastasis suppressor gene KiSS-1 in cancer. *Cancer Res*. 2002;62(21):5934–5938. PMID: 12384551

9. d’Anglemont de Tassigny X, Colledge WH. The role of kisspeptin signaling in reproductive function. *Endocrinology*. 2010;151(9):3765–3773. doi:10.1210/en.2010-0026

10. Chan YM, et al. Kisspeptin resets the GnRH pulse generator in humans. *J Clin Endocrinol Metab*. 2011;96(8):E1212–E1221. doi:10.1210/jc.2011-0066