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KPV

KPV

$46.00
$46.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

science Lab-Tested 99% Purity

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KPV

KPV

$46.00
$46.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

KPV is a tripeptide fragment (Lys-Pro-Val) derived from the C-terminal sequence of α-melanocyte-stimulating hormone (α-MSH). It has been studied for its anti-inflammatory and immunomodulatory properties, particularly its ability to reduce pro-inflammatory cytokine activity and support tissue repair.

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  • DESCRIPTION
  • STORAGE
  • REFERENCES

KPV (Lys-Pro-Val) is a naturally occurring tripeptide fragment derived from the C-terminal sequence of α-melanocyte-stimulating hormone (α-MSH). It retains the anti-inflammatory and immunomodulatory effects of α-MSH while lacking the pigmentation activity associated with the full-length hormone. KPV has been studied for its ability to suppress inflammatory pathways, reduce oxidative stress, and promote tissue healing in gastrointestinal, dermatological, and systemic disease models.

Structure

  • Sequence: Lys-Pro-Val
  • Length: 3 amino acids (tripeptide)
  • Molecular Weight: ~341 Da
  • Mechanism: Inhibits NF-κB signaling, reduces pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), and promotes immune balance

Research

Anti-Inflammatory Actions

  • Potently suppresses NF-κB activation, reducing cytokine and chemokine expression.
  • Demonstrates strong effects in models of colitis, dermatitis, and systemic inflammation.

Gastrointestinal Health

  • KPV reduces intestinal inflammation and protects epithelial integrity in IBD models.
  • Shown to decrease tissue damage in experimental ulcerative colitis.

Dermatological Research

  • Reduces skin inflammation and erythema, making it of interest in eczema and psoriasis research.
  • Demonstrates wound-healing potential through anti-inflammatory and antioxidant actions.

Systemic & Immune Effects

  • Modulates innate immune responses, reducing neutrophil infiltration and oxidative damage.
  • Studied in models of sepsis, arthritis, and inflammatory lung injury.

Safety Profile

  • Small, naturally derived peptide with favorable tolerability in animal studies.
  • Lacks melanotropic side effects seen with α-MSH.

Summary

KPV is a tripeptide fragment of α-MSH with potent anti-inflammatory, antioxidant, and tissue-protective properties. Research highlights include:

  • Suppresses NF-κB and pro-inflammatory cytokines
  • Protects GI tract in IBD and colitis models
  • Reduces skin inflammation in dermatitis and wound healing research
  • Potential as a safe immunomodulatory therapeutic candidate

This peptide is supplied as a lyophilized powder. Store vials at 2–8 °C, protected from light and moisture. For long-term preservation, keep unopened vials at −20 °C. After reconstitution, prepare solutions under sterile conditions, refrigerate at 2–8 °C, and use promptly. Avoid repeated freeze–thaw cycles.

1. Star RA, Rajora N, Huang J, et al. α-MSH and related tripeptide KPV inhibit endotoxin-induced inflammation. *J Pharmacol Exp Ther*. 1995;273(2):1253–1259. PMID: 7752097

2. Getting SJ, et al. The melanocortin peptide KPV exerts anti-inflammatory effects in murine colitis. *J Immunol*. 1999;162(3):1616–1623. PMID: 9973401

3. Catania A, Lipton JM. Anti-inflammatory actions of alpha-MSH and related peptides. *Endocr Rev*. 1993;14(5):564–576. doi:10.1210/edrv-14-5-564

4. Rajora N, et al. α-MSH and KPV reduce inflammatory cytokine production in sepsis. *J Leukoc Biol*. 1996;59(2):248–253. doi:10.1002/jlb.59.2.248

5. Rajendran R, et al. Tripeptide KPV reduces cytokine activity and intestinal inflammation. *Peptides*. 2003;24(3):397–402. doi:10.1016/S0196-9781(03)00095-1

6. Brzoska T, et al. Melanocortins in skin inflammation: KPV suppresses contact dermatitis. *J Invest Dermatol*. 1999;113(4):465–471. doi:10.1046/j.1523-1747.1999.00731.x

7. Taylor AW, Lee DJ. The anti-inflammatory properties of α-MSH tripeptide derivatives. *Front Immunol*. 2014;5:173. doi:10.3389/fimmu.2014.00173

8. Luger TA, Brzoska T. α-MSH and related peptides: bioregulators for immune and inflammatory responses. *Ann N Y Acad Sci*. 2007;1110:372–381. doi:10.1196/annals.1423.040

9. Catania A, et al. The melanocortin system in inflammation. *Pharmacol Rev*. 2004;56(1):1–29. doi:10.1124/pr.56.1.1

10. Getting SJ. Melanocortin peptides and their anti-inflammatory role: focus on KPV. *Peptides*. 2006;27(2):431–438. doi:10.1016/j.peptides.2005.02.021