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MOTS-c

MOTS-c

$52.00
$52.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

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MOTS-c

MOTS-c

$52.00
$52.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

MOTS-c is a 16–amino acid peptide encoded by mitochondrial DNA that regulates cellular energy metabolism. It has been studied for its ability to enhance insulin sensitivity, promote fatty acid oxidation, and protect against metabolic stress, linking mitochondrial function to systemic metabolic health.

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  • DESCRIPTION
  • STORAGE
  • REFERENCES

MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the 12S rRNA region of mitochondrial DNA. Comprising 16 amino acids, MOTS-c acts as a regulator of cellular metabolism, stress resistance, and energy homeostasis. It is highly expressed in skeletal muscle and circulates systemically, where it influences glucose metabolism, insulin sensitivity, fat utilization, and longevity-related pathways. MOTS-c is of growing interest in research on aging, metabolic disorders, exercise physiology, and mitochondrial biology.

Structure

  • Type: Mitochondrial-derived peptide (MDP)
  • Sequence: MRWQEMGYIFYPRKLR
  • Length: 16 amino acids
  • Molecular Weight: ~1.8 kDa
  • Mechanism:



    Activates AMPK signaling → ↑ glucose uptake, ↑ fatty acid oxidation



    Enhances cellular stress adaptation and mitochondrial communication with the nucleus

Research

Metabolic Regulation

  • Improves insulin sensitivity and glucose metabolism in skeletal muscle.
  • Promotes fat oxidation while reducing fat accumulation in adipose tissue.

Exercise & Performance

  • Enhances exercise capacity and metabolic flexibility.
  • Shown to mimic some benefits of endurance training at the molecular level.

Longevity & Aging

  • Levels decline with age; supplementation improves healthspan markers in animal models.
  • Activates cytoprotective pathways linked to mitochondrial-nuclear communication.

Stress Adaptation

  • Protects against oxidative stress and metabolic dysfunction
  • Increases resilience to diet-induced obesity and metabolic syndrome.

Safety Profile

  • Endogenously expressed in humans.
  • Well tolerated in animal and early human studies.

Summary

MOTS-c is a mitochondrial-encoded regulatory peptide with broad effects on metabolism, stress response, and healthy aging. Research highlights include:

  • Improves glucose metabolism and insulin sensitivity
  • Enhances exercise performance and endurance
  • Activates AMPK and cytoprotective pathways
  • Potential applications in aging, obesity, and metabolic syndrome research

This peptide is supplied as a lyophilized powder. Store vials at 2–8 °C, protected from light and moisture. For long-term preservation, keep unopened vials at −20 °C. After reconstitution, prepare solutions under sterile conditions, refrigerate at 2–8 °C, and use promptly. Avoid repeated freeze–thaw cycles.

1. Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity. *Cell Metab*. 2015;21(3):443–454. doi:10.1016/j.cmet.2015.02.009

2. Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. *Nat Commun*. 2021;12(1):470. doi:10.1038/s41467-020-20790-0

3. Kim KH, et al. MOTS-c: a novel mitochondrial-derived peptide regulating muscle and metabolic homeostasis. *Free Radic Biol Med*. 2018;100:182–187. doi:10.1016/j.freeradbiomed.2016.04.023

4. Zarse K, et al. Mitochondrial peptides as mediators of inter-organelle signaling: role of MOTS-c. *Aging Cell*. 2019;18(2):e12845. doi:10.1111/acel.12845

5. Lu H, et al. MOTS-c prevents diet-induced obesity and insulin resistance in mice. *Aging (Albany NY)*. 2018;10(11): 1–12. doi:10.18632/aging.101630

6. Yong C, et al. MOTS-c improves insulin resistance by activating AMPK and enhancing glucose uptake. *Biochem Biophys Res Commun*. 2016;473(2):425–431. doi:10.1016/j.bbrc.2016.03.109

7. Ramanjaneya M, et al. Circulating MOTS-c levels in aging and metabolic disease. *Clin Endocrinol (Oxf)*. 2019;91(5):697–705. doi:10.1111/cen.14089

8. Miller B, et al. MOTS-c enhances exercise performance and muscle metabolism. *J Cachexia Sarcopenia Muscle*. 2021;12(6):1642–1656. doi:10.1002/jcsm.12748

9. Zhao Y, et al. MOTS-c as a potential therapeutic peptide for age-related disease. *Front Endocrinol (Lausanne)*. 2019;10:438. doi:10.3389/fendo.2019.00438

10. Du C, et al. MOTS-c as a regulator of mitochondrial signaling and metabolic adaptation. *Trends Endocrinol Metab*. 2022;33(1):25–37. doi:10.1016/j.tem.2021.10.001