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NAD+

NAD+

$52.00
$52.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

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NAD+

NAD+

$52.00
$52.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

Nicotinamide Adenine Dinucleotide (NAD⁺) is a vital coenzyme present in all living cells that functions as an electron carrier in redox reactions. It plays a central role in energy metabolism, DNA repair, and cell signaling, and declining levels have been associated with aging and metabolic dysfunction.

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  • DESCRIPTION
  • STORAGE
  • REFERENCES

Nicotinamide adenine dinucleotide (NAD⁺) is a vital redox coenzyme found in all living cells. It plays a central role in cellular metabolism, mitochondrial function, and energy production. Beyond redox reactions, NAD⁺ is a substrate for key enzymes including sirtuins, PARPs, and CD38, which regulate DNA repair, epigenetics, circadian rhythm, immune function, and aging processes. Research into NAD⁺ and its precursors (NMN, NR, niacin) has expanded significantly in recent years due to its role in longevity, metabolic disorders, and neuroprotection.

Structure

  • Type: Pyridine nucleotide coenzyme
  • Chemical Formula: C₂₁H₂₇N₇O₁₄P₂
  • Molecular Weight: ~663 Da
  • Forms: NAD⁺ (oxidized), NADH (reduced), NADP⁺/NADPH (phosphorylated forms)
  • Mechanism:

    Functions as an electron carrier in redox reactions



    Serves as a substrate for NAD⁺-consuming enzymes (sirtuins, PARPs, CD38)



    Central to metabolic regulation, stress response, and cell survival

Research

Energy Metabolism

  • Essential in glycolysis, TCA cycle, and oxidative phosphorylation.
  • Couples redox reactions to ATP production.

DNA Repair & Genomic Stability

  • Substrate for PARPs, which repair DNA damage.
  • Supports genome integrity under oxidative stress.

Aging & Longevity

  • NAD⁺ levels decline with age.
  • Restoring NAD⁺ improves mitochondrial function, insulin sensitivity, and lifespan markers in animal models.

Neuroprotection

  • Enhances neuronal resilience in models of Alzheimer’s, Parkinson’s, and stroke.
  • Supports synaptic plasticity and cognitive performance.

Immune & Metabolic Health

  • Modulates inflammation, circadian rhythm, and stress responses.
  • Investigated in obesity, type 2 diabetes, and cardiovascular disorders.

Safety Profile

  • Endogenous metabolite; supplementation via precursors (NMN, NR, NA) is generally safe.
  • Clinical trials report mild side effects (GI upset, flushing with niacin).

Summary

NAD⁺ is a central metabolic coenzyme and signaling molecule with research applications in:

  • Energy metabolism & mitochondrial function
  • Aging and longevity research
  • Neuroprotection and DNA repair
  • Immune modulation and metabolic health

This compound is supplied as a lyophilized powder. Store at 2–8 °C, protected from light and moisture. For long-term preservation, keep unopened vials at −20 °C. After reconstitution, prepare solutions under sterile conditions, refrigerate at 2–8 °C, and use promptly. Avoid repeated freeze–thaw cycles.

1. Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD⁺ precursor vitamins. *Annu Rev Nutr*. 2008;28:115–130. doi:10.1146/annurev.nutr.28.061807.155443

2. Verdin E. NAD⁺ in aging, metabolism, and neurodegeneration. *Science*. 2015;350(6265):1208–1213. doi:10.1126/science.aac4854

3. Imai SI, Guarente L. NAD⁺ and sirtuins in aging and disease. *Trends Cell Biol*. 2014;24(8):464–471. doi:10.1016/j.tcb.2014.04.002

4. Ying W. NAD⁺ and NADH in cellular functions and cell death. *Front Biosci*. 2006;11:3129–3148. doi:10.2741/2038

5. Rajman L, et al. Therapeutic potential of NAD⁺ precursors in health and disease. *Nat Rev Drug Discov*. 2018;17(9):651–669. doi:10.1038/nrd.2018.98

6. Lautrup S, et al. NAD⁺ in brain aging and neurodegenerative disorders. *Cell Metab*. 2019;30(4):630–655. doi:10.1016/j.cmet.2019.09.001

7. Canto C, et al. NAD⁺ metabolism and the control of energy homeostasis. *Trends Mol Med*. 2015;21(6):429–441. doi:10.1016/j.molmed.2015.03.001

8. Yoshino J, et al. Nicotinamide mononucleotide, a key NAD⁺ intermediate, treats diet- and age-induced diabetes in mice. *Cell Metab*. 2011;14(4):528–536. doi:10.1016/j.cmet.2011.08.014

9. Trammell SAJ, et al. Nicotinamide riboside is a newly discovered NAD⁺ precursor vitamin in humans. *Nat Commun*. 2016;7:12948. doi:10.1038/ncomms12948

10. Fang EF, et al. NAD⁺ replenishment improves mitochondrial and stem cell function and enhances life span in mice. *Science*. 2016;352(6292):1436–1443. doi:10.1126/science.aaf2693