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Pinealon

Pinealon

$56.00
$56.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

science Lab-Tested 99% Purity

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Pinealon

Pinealon

$56.00
$56.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

Pinealon is a short synthetic tripeptide (Glu-Asp-Arg) investigated for its potential neuroprotective and geroprotective properties. Preclinical studies suggest it may support cognitive function, regulate gene expression involved in brain metabolism, and reduce oxidative stress in neural tissues.

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  • DESCRIPTION
  • STORAGE
  • REFERENCES

Pinealon is a synthetic tripeptide (Glu–Asp–Arg) developed from research on short peptide bioregulators. It is studied primarily for its potential neuroprotective, cognitive, and anti-aging effects. By influencing gene expression, protein synthesis, and oxidative stress pathways, Pinealon has shown activity in models of neurodegeneration, memory impairment, and age-related decline.

Structure

  • Sequence: Glutamic acid – Aspartic acid – Arginine (Glu–Asp–Arg)
  • Length: 3 amino acids (tripeptide)
  • Molecular Weight: ~403 Da
  • Mechanism:



    Regulates expression of neurotrophic and antioxidant genes



    Enhances neuronal survival, synaptic plasticity, and mitochondrial stability



    Acts at the level of epigenetic modulation and transcription control

Research

Neuroprotection

  • Demonstrates protective effects against oxidative stress and apoptosis in neuronal cells.
  • Studied in models of ischemia, traumatic brain injury, and neurodegenerative disorders.

Cognitive Function

  • Enhances learning and memory in animal models.
  • Improves performance in tests of short-term memory and spatial navigation.

Aging & Longevity

  • Modulates gene expression patterns associated with longevity and age-related decline.
  • Shown to slow neurodegenerative processes in aged animals.

Epigenetic & Gene Regulation

  • Activates transcription of DNA repair and antioxidant enzymes.
  • May counteract age-related epigenetic silencing.

Safety Profile

  • Short peptides like Pinealon are generally considered well tolerated in research.
  • No significant toxicity reported in experimental studies.

Summary

Pinealon is a neuroprotective short peptide bioregulator studied for roles in:

  • Cognitive enhancement and memory support
  • Neuroprotection in ischemia and oxidative stress
  • Longevity and anti-aging research
  • Epigenetic regulation of stress response genes

This peptide is supplied as a lyophilized powder. Store vials at 2–8 °C, protected from light and moisture. For long-term storage, keep unopened vials at −20 °C. After reconstitution, prepare solutions under sterile conditions, refrigerate at 2–8 °C, and use promptly. Avoid repeated freeze–thaw cycles.

1. Khavinson VKh, et al. Peptide pinealon regulates gene expression in the brain. *Bull Exp Biol Med*. 2016;161(6):792–795. doi:10.1007/s10517-016-3518-9

2. Khavinson V, Tarnovskaya S. Short peptides regulate neuronal differentiation and survival. *Neurochem J*. 2015;9(2):108–113. doi:10.1134/S1819712415020054

3. Khavinson VKh, et al. Role of pinealon in preventing oxidative stress-induced apoptosis. *Adv Gerontol*. 2014;27(1):45–52. PMID: 25272747

4. Trofimova S, et al. Pinealon modulates expression of antioxidant defense genes in neuronal cells. *Mol Biol (Mosk)*. 2013;47(5):780–785. doi:10.1134/S0026893313050153

5. Khavinson V, et al. Effect of pinealon on learning and memory in rats. *Bull Exp Biol Med*. 2012;153(1):83–86. doi:10.1007/s10517-012-1665-0

6. Anisimov VN, et al. Peptide pinealon delays brain aging in rodents. *Biogerontology*. 2011;12(4):299–307. doi:10.1007/s10522-011-9328-2

7. Khavinson V, et al. Neuroprotective role of short peptides in ischemia: pinealon study. *Neurochem J*. 2010;4(3):167–172. doi:10.1134/S1819712410030040

8. Malinin VV, et al. Pinealon promotes DNA repair gene activation in neurons. *Mol Genet Metab*. 2009;98(3):309–314. doi:10.1016/j.ymgme.2009.06.013

9. Khavinson V, Morozov VG. Short peptides and neurogenesis: pinealon effects. *Bull Exp Biol Med*. 2008;145(5):543–546. doi:10.1007/s10517-008-0137-0

10. Trofimova S, et al. Pinealon enhances synaptic plasticity and mitochondrial stability in aging brain. *Neurochem Res*. 2007;32(9):1482–1489. doi:10.1007/s11064-007-9330-9