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Selank

Selank

$48.00
$48.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

science Lab-Tested 99% Purity

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Selank

Selank

$48.00
$48.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

Selank is a synthetic heptapeptide analog of the endogenous tetrapeptide tuftsin, developed for its neuromodulatory and anxiolytic properties. It has been studied for its ability to regulate monoamine neurotransmitters, modulate the expression of brain-derived neurotrophic factor (BDNF), and support cognitive and stress resilience.

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  • DESCRIPTION
  • STORAGE
  • REFERENCES

Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the natural immunomodulatory peptide tuftsin. It is studied for its anxiolytic, nootropic, and immunomodulatory effects. Selank modulates monoamine neurotransmission, GABAergic signaling, and immune responses, making it a candidate in research on anxiety, depression, stress adaptation, and cognitive enhancement.

Structure

  • Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
  • Length: 7 amino acids (heptapeptide)
  • Molecular Weight: ~751 Da
  • Mechanism:



    Modulates serotonin and dopamine metabolism



    Enhances GABA receptor expression



    Regulates cytokine production and balances Th1/Th2 immune responses

Research

Anxiolytic & Antidepressant Effects

  • Demonstrates anxiolytic activity without sedation or dependency risk (unlike benzodiazepines).
  • Improves mood, stress resilience, and cognitive performance in animal and human studies.

Nootropic Properties

  • Enhances learning, memory consolidation, and attention span.
  • Shown to improve cognitive performance under stress conditions.

Immune Modulation

  • Derived from tuftsin, Selank enhances immune function, increasing resistance to infections.
  • Balances pro- and anti-inflammatory cytokines, supporting stress-related immune regulation.

Stress Adaptation

  • Prevents stress-induced cognitive decline and anxiety-like behaviors.
  • Modulates HPA axis and normalizes neurotransmitter balance.

Safety Profile

  • Reported as non-toxic, non-addictive, and well tolerated in research.
  • No evidence of withdrawal or abuse potential.

Summary

Selank is a tuftsin-derived neuropeptide analogue with broad effects on the nervous and immune systems. Research highlights include:

  • Anxiolytic and antidepressant activity without sedation
  • Cognitive enhancement in memory and learning tasks
  • Immune-modulating properties supporting stress adaptation
  • Potential role in neuropsychiatric and neurodegenerative research

This peptide is supplied as a lyophilized powder. Store vials at 2–8 °C, protected from light and moisture. For long-term preservation, keep unopened vials at −20 °C. After reconstitution, prepare under sterile conditions, refrigerate at 2–8 °C, and use promptly. Avoid repeated freeze–thaw cycles.

1. Ashmarin IP, et al. Neuropeptide Selank: development and mechanisms of action. *Bull Exp Biol Med*. 2005;139(2):169–173. doi:10.1007/s10517-005-0244-3

2. Andreeva LA, et al. Selank’s anxiolytic activity compared with benzodiazepines. *Neurochem J*. 2012;6(1):56–63. doi:10.1134/S1819712412010038

3. Inozemtsev AN, et al. Selank improves memory and learning in animal models. *J Evol Biochem Physiol*. 2008;44(3):335–342. doi:10.1134/S0022093008030149

4. Medvedev AE, et al. Tuftsin analog Selank regulates cytokine expression. *Bull Exp Biol Med*. 2007;143(3):295–298. doi:10.1007/s10517-007-0121-8

5. Kozlovskaya MM, et al. Selank modulates serotonin metabolism in the brain. *Neurochem J*. 2010;4(2):122–128. doi:10.1134/S1819712410020048

6. Dolotov OV, et al. Selank upregulates GABA receptor expression in rat hippocampus. *Neurochem J*. 2011;5(3):168–174. doi:10.1134/S1819712411030020

7. Inozemtsev AN, et al. Stress-protective effects of Selank on cognitive function. *Neurochem Res*. 2009;34(10):1810–1816. doi:10.1007/s11064-009-9957-4

8. Neznanov NG, et al. Selank in the regulation of behavior and immunity. *Neurosci Behav Physiol*. 2002;32(6):639–643. doi:10.1023/A:1020237427095

9. Andreeva LA, et al. Selank’s role in depression-related research. *Bull Exp Biol Med*. 2013;155(1):98–101. doi:10.1007/s10517-013-2077-7

10. Medvedev AE, et al. Clinical evaluation of Selank as an anxiolytic peptide. *Zh Nevrol Psikhiatr Im S S Korsakova*. 2004;104(5):57–62. PMID: 15216793