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Semax

Semax

$48.00
$48.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

science Lab-Tested 99% Purity

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Semax

Semax

$48.00
$48.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

Semax is a synthetic heptapeptide analogue of adrenocorticotropic hormone (ACTH₄₋₁₀) developed in Russia for neuroprotective and nootropic applications. Research indicates it may enhance cognitive function, modulate neurotrophic factors such as BDNF, and provide protection against ischemic brain injury.

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  • DESCRIPTION
  • STORAGE
  • REFERENCES

Semax is a synthetic heptapeptide analogue (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the adrenocorticotropic hormone (ACTH₄–₁₀) fragment, with modifications to enhance stability and neurotropic activity. Unlike ACTH, Semax lacks hormonal (corticosteroid-related) activity but retains and amplifies neuromodulatory, neuroprotective, and nootropic properties. It has been studied extensively in Russia for use in stroke recovery, traumatic brain injury, optic nerve disorders, cognitive enhancement, and stress adaptation.

Structure

  • Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
  • Length: 7 amino acids (heptapeptide)
  • Molecular Weight: ~940 Da
  • Mechanism:



    Enhances neurotrophin (BDNF, NGF) expression



    Modulates dopaminergic and serotonergic systems



    Protects neurons from hypoxia, ischemia, and oxidative stress



    Promotes synaptic plasticity and cognitive resilience

Research

Neuroprotection

  • Reduces neuronal death after ischemic stroke and traumatic brain injury.
  • Protects against oxidative stress, glutamate toxicity, and apoptosis.

Cognitive Enhancement

  • Improves learning, memory, and attention in both healthy subjects and models of impairment.
  • Increases BDNF signaling, critical for neuroplasticity.

Vision & Optic Nerve Disorders

  • Studied in optic neuropathies and glaucoma, improving retinal and optic nerve function.

Stress Adaptation

  • Regulates dopamine and serotonin balance, enhancing resilience to psychological and physical stress.

Clinical Research

  • Used in Russia as a nasal spray for stroke rehabilitation and cognitive disorders.


  • Shown to accelerate neurological recovery in ischemic conditions.

Safety Profile

  • Well tolerated in research; non-toxic in animal and clinical studies.
  • No evidence of addiction or hormonal side effects.

Summary

Semax is a synthetic ACTH fragment analogue with strong neuroprotective and nootropic effects. Research highlights include:

  • Stroke recovery and ischemic protection
  • Memory, learning, and cognitive enhancement
  • Optic nerve and retinal neuroprotection
  • Stress adaptation and mood regulation

This peptide is supplied as a lyophilized powder. Store vials at 2–8 °C, protected from light and moisture. For long-term preservation, keep unopened vials at −20 °C. After reconstitution, prepare under sterile conditions, refrigerate at 2–8 °C, and use promptly. Avoid repeated freeze–thaw cycles.

1. Ashmarin IP, et al. Neuroprotective properties of Semax: mechanisms and applications. *Bull Exp Biol Med*. 1999;127(2):163–169. doi:10.1007/BF02446152

2. Skorobogatova EV, et al. Semax in complex therapy of ischemic stroke: clinical outcomes. *Neurosci Behav Physiol*. 2001;31(2):209–214. doi:10.1023/A:1010329116517

3. Myasoedov NF, et al. Peptide Semax regulates gene expression related to neuroprotection. *Mol Biol (Mosk)*. 2005;39(2):291–298. PMID: 15859370

4. Andreeva LA, et al. Semax improves cognitive function in experimental models. *Neurochem J*. 2009;3(2):89–94. doi:10.1134/S1819712409020029

5. Dolotov OV, et al. Semax upregulates BDNF and NGF expression in the brain. *Bull Exp Biol Med*. 2006;141(5):573–576. doi:10.1007/s10517-006-0220-2

6. Ashmarin IP, et al. Stress-protective effects of Semax: influence on neurotransmitter systems. *Neurochem Res*. 2000;25(9-10):1265–1272. doi:10.1023/A:1007699917139

7. Skorobogatova EV, et al. Semax therapy improves visual function in optic neuropathies. *Vestn Oftalmol*. 2002;118(6):23–27. PMID: 12577542

8. Inozemtsev AN, et al. Role of Semax in modulation of monoamine metabolism. *Neurochem Int*. 2003;42(5):425–431. doi:10.1016/S0197-0186(02)00135-7

9. Myasoedov NF, et al. Semax and regulation of gene expression in ischemia. *Brain Res Bull*. 2008;75(2-4):238–244. doi:10.1016/j.brainresbull.2007.10.017

10. Dolotov OV, et al. Semax-induced neuroprotection against hypoxic injury. *Neurochem J*. 2011;5(1):46–51. doi:10.1134/S1819712411010057