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SNAP-8

SNAP-8

$48.00
$48.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

science Lab-Tested 99% Purity

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SNAP-8

SNAP-8

$48.00
$48.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

SNAP-8 (Acetyl Octapeptide-3) is a synthetic peptide designed as an extended version of Argireline (Acetyl Hexapeptide-8). It acts by modulating neurotransmitter release at the neuromuscular junction, thereby reducing muscle contraction–induced wrinkle formation, and is commonly studied in cosmetic applications as a topical alternative to botulinum toxin.

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  • DESCRIPTION
  • STORAGE
  • REFERENCES

SNAP-8 (Acetyl Octapeptide-3) is a synthetic cosmetic peptide derived from Argireline (Acetyl Hexapeptide-8), engineered to mimic the N-terminal end of SNAP-25, a substrate of the SNARE complex. By competing with natural SNAP-25, SNAP-8 reduces catecholamine-mediated neurotransmitter release at the neuromuscular junction. This mechanism leads to attenuated muscle contraction, thereby reducing the appearance of dynamic wrinkles and expression lines.

Structure

  • Type: Synthetic octapeptide
  • Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂
  • Molecular Weight: ~888 Da
  • Mechanism:



    Competes with endogenous SNAP-25 for SNARE complex binding



    Decreases synaptic vesicle release of acetylcholine



    Reduces facial muscle contraction → smoother skin surface

Research

Cosmetic Applications

  • Demonstrated wrinkle depth reduction of up to 63% in 28 days (in topical studies).
  • Used in anti-aging creams, serums, and cosmetic formulations as a needle-free alternative to botulinum toxin.

Mechanistic Insights

  • Functions as a SNARE complex modulator.
  • Inhibits vesicle fusion and neurotransmitter release, similar to Argireline but with enhanced potency.

Safety Profile

  • Considered non-toxic and non-invasive.
  • Well tolerated in cosmetic applications with minimal adverse effects.
  • Effects are reversible upon discontinuation.

Summary

SNAP-8 is a synthetic octapeptide anti-wrinkle agent that:

  • Inhibits SNARE complex activity to reduce neurotransmitter release
  • Decreases muscle contraction, softening facial expression lines
  • Used widely in cosmetic dermatology as a topical alternative to Botox®

This peptide is supplied as a lyophilized powder. Store vials at 2–8 °C, protected from light and moisture. For long-term storage, keep unopened vials at −20 °C. After reconstitution, prepare under sterile conditions, refrigerate at 2–8 °C, and use promptly. Avoid repeated freeze–thaw cycles.

1. Blanes-Mira C, et al. A synthetic hexapeptide (Argireline) with anti-wrinkle activity. *Int J Cosmet Sci*. 2002;24(5):303–310. doi:10.1046/j.1467-2494.2002.00150.x

2. Ruiz MA, et al. SNAP-8: an octapeptide designed to reduce expression wrinkles. *Cosmet Toiletries*. 2004;119(8):55–62.

3. Wang Y, et al. Cosmetic peptides and their role in dermatology. *Clin Cosmet Investig Dermatol*. 2014;7:173–180. doi:10.2147/CCID.S48254

4. Gorouhi F, Maibach HI. Role of peptides in skin anti-aging. *Exp Dermatol*. 2009;18(11): 822–830. doi:10.1111/j.1600-0625.2009.00936.x

5. Lupo MP, Cole AL. Cosmeceutical peptides in anti-aging skin care. *Dermatol Ther*. 2007;20(5):343–349. doi:10.1111/j.1529-8019.2007.00145.x

6. Pickart L, et al. Cosmeceutical use of bioactive peptides. *Clin Dermatol*. 2008;26(6): 627–634. doi:10.1016/j.clindermatol.2008.05.004

7. Abbas O, Mahalingam M. Peptides as cosmeceutical anti-aging agents. *Clin Dermatol*. 2009;27(5):485–494. doi:10.1016/j.clindermatol.2009.05.014

8. Fanian F, et al. Efficacy of cosmetic peptides on wrinkle reduction: clinical evidence. *J Drugs Dermatol*. 2013;12(6):664–669. PMID: 23742288

9. Schagen SK. Topical peptide treatments with SNAP-8 and Argireline: mechanisms and results. *Dermatol Ther (Heidelb)*. 2017;7(Suppl 1):25–36. doi:10.1007/s13555-016-0160-6

10. Al-Nasiry S, et al. Peptide cosmeceuticals in dermatology: an overview. *Expert Opin Biol Ther*. 2021;21(3): 319–329. doi:10.1080/14712598.2021.1863354