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TB-500

TB-500

$58.00
$58.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

science Lab-Tested 99% Purity

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TB-500

TB-500

$58.00
$58.00
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

TB-500 (Thymosin Beta-4 Fragment) is a synthetic peptide consisting of the active region of thymosin beta-4. It has been studied for its ability to promote angiogenesis, support wound healing, enhance cell migration, and reduce inflammation in various tissues.

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  • DESCRIPTION
  • STORAGE
  • REFERENCES

TB-500 is a synthetic peptide fragment of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid protein involved in cell migration, angiogenesis, and wound repair. TB-500 represents the active G-actin–binding region of Tβ4, responsible for many of its regenerative and repair-related effects. It is studied for its roles in tissue healing, angiogenesis, cytoprotection, and inflammation modulation.

Structure

  • Type: Synthetic peptide (Tβ4 fragment)
  • Sequence: Derived from Tβ4 (43 aa), containing actin-binding motif
  • Molecular Weight: ~4963 Da (for full-length Tβ4; TB-500 fragment varies ~4–5 kDa)
  • Mechanism:



    Binds to G-actin, regulating cytoskeletal dynamics



    Promotes cell migration, differentiation, and wound closure



    Stimulates angiogenesis via VEGF-related pathways



    Reduces apoptosis and oxidative stress in damaged tissues

Research

Wound Healing & Tissue Repair

  • Enhances keratinocyte and endothelial migration.
  • Improves epithelial regeneration in skin, cornea, and mucosal tissue.

Cardioprotection

  • Protects myocardium after ischemic injury.
  • Improves angiogenesis and repair following cardiac damage.

Muscle & Tendon Regeneration

  • Accelerates muscle repair in preclinical injury models.
  • Supports collagen deposition and tendon healing.

Neuroprotection

  • Demonstrates protective effects in neurodegenerative models.
  • Promotes neurite outgrowth and survival.

Anti-Inflammatory Effects

  • Modulates cytokine release.
  • Reduces tissue fibrosis and scar formation.

Safety Profile

  • Preclinical and early clinical data suggest a favorable safety profile.
  • No major adverse effects reported in experimental use.

Summary

TB-500 is a bioactive fragment of Thymosin Beta-4 that:

  • Promotes tissue regeneration and wound healing
  • Enhances angiogenesis and cytoprotection
  • Provides cardio- and neuroprotection in experimental studies
  • Studied as a therapeutic candidate in regenerative medicine

This peptide is supplied as a lyophilized powder. Store vials at 2–8 °C, protected from light and moisture. For long-term preservation, keep unopened vials at −20 °C. After reconstitution, prepare under sterile conditions, refrigerate at 2–8 °C, and use promptly. Avoid repeated freeze–thaw cycles.

1. Goldstein AL, et al. Thymosin beta 4: a multifunctional tissue repair and regeneration peptide. *Ann N Y Acad Sci*. 2012;1269:92–101. doi:10.1111/j.1749-6632.2012.06737.x

2. Sosne G, et al. Thymosin beta 4 promotes corneal wound healing. *Invest Ophthalmol Vis Sci*. 2002;43(12):3820–3827. PMID: 12454047

3. Malinda KM, et al. Thymosin beta 4 stimulates directional migration of endothelial cells. *J Cell Sci*. 1997;110(Pt 19):2285–2295. doi:10.1242/jcs.110.19.2285

4. Crockford D. Development of thymosin beta 4 for treatment of heart failure and stroke. *Ann N Y Acad Sci*. 2007;1112:385–395. doi:10.1196/annals.1415.011

5. Bock-Marquette I, et al. Thymosin beta 4 activates integrin-linked kinase and promotes cardiac cell migration and survival. *Nature*. 2004;432(7016):466–472. doi:10.1038/nature03000

6. Smart N, et al. Thymosin beta 4 induces adult epicardial progenitor mobilization and neovascularization. *Nature*. 2007;445(7124):177–182. doi:10.1038/nature05383

7. Morris DC, et al. Neuroprotective potential of thymosin beta 4 in experimental stroke. *Neurobiol Dis*. 2010;40(1):36–44. doi:10.1016/j.nbd.2010.05.003

8. Philp D, et al. Thymosin beta 4 reduces inflammation and fibrosis in wound healing. *J Invest Dermatol*. 2004;122(5):1137–1146. doi:10.1111/j.0022-202X.2004.22411.x

9. Wei L, et al. Thymosin beta 4 improves neurological recovery and angiogenesis after stroke in rats. *Ann Neurol*. 2007;61(3):281–292. doi:10.1002/ana.21076

10. Grant DS, et al. Thymosin beta 4 promotes angiogenesis and endothelial cell differentiation. *FASEB J*. 1995;9(10): 1402–1409. doi:10.1096/fasebj.9.10.7615153